KRas-ERK signalling promotes the onset and maintenance of uveal melanoma through regulating JMJD6-mediated H2A.X phosphorylation at tyrosine 39

Yaping Li,Peng Yu,Ying Zou,Wenrui Cai,Weixuan Sun,Ning Han

KRas-ERK signalling promotes the onset and maintenance of uveal melanoma through regulating JMJD6-mediated H2A.X phosphorylation at tyrosine 39

2019

Yaping Li
Peng Yu
Ying Zou
Wenrui Cai
Weixuan Sun
Ning Han

AbstractSince DNA damage is a first incident occurred during a tumour attack, it is rational that histone H2A.X phosphorylation on tyrosine 39 (H2A.XY39ph) may act as a tumour-relevant factor. This...

Keywords:

DNA damage
KRAS
Phosphorylation
Cancer research
MAPK/ERK pathway
Tyrosine
Histone H2A
Biochemistry
Melanoma
Materials science
Mdm2

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