pleuropulmonary involvement in connective tissue disorders in a tertiary care hospital in africa
2018
1. Abstract 1.1 Background: Pleuropulmonary
manifestations are very common and associated with high mortality in patients
with Connective Tissue Disorders (CTDs). Their frequency and patterns are
variable depending on the type of CTD. Limited data is available in these
patients in Sub-Saharan Africa. 1.2 Aim: To study the
spectrum of pleuropulmonary manifestations of CTDs in a tertiary hospital in
Douala, Cameroon. 1.3 Methods: This was a cross
sectional hospital-based study, including CTD patients recruited in the Douala
general hospital Rheumatology and Chest Medicine clinics. CTD was defined
according to the American College of Rheumatology and European League against
Rheumatism (ACR/EULAR) criteria. Between January and August 2016, all
consenting adult patients with various CTDs were assessed for pleuropulmonary
involvement using a clinical examination, Chest X-Ray (CXR), Pulmonary Function
Tests (PFT) and High Resonance Computed Tomography (HRCT). 1.4 Results: We included 54
CTD patients, 29 had Rheumatoid Arthritis (RA), 16 Systemic Lupus Erythematosus
(SLE), 7 scleroderma (SSc) and 2 Mixed Connective Tissue Disease (MCTD).
Pulmonary clinical signs and symptoms were present in 18 patients (33.3%) with
dyspnea (27.8%) and cough (13.0%) being more predominant. Chest HRCT revealed mostly
Interstitial Lung Disease (ILD) patterns in 16 patients (29.6%) with honeycombing
lesions occurring in 9.3% of CTD patients, (10.3% of RA patients and 28.6% of
SSc patients) and Ground glass lesions occurring in 5.6% of CTD patients [1/29
RA (3.4%) and 2/7 scleroderma patients (28.6%)]. PFTs abnormalities were seen in 51.9% of CTD
patients (28/54) and restrictive defect was the most common abnormality as seen
in 41.4% of RA patients,71.4% of scleroderma patients, 56.2% of SLE patients
and 50.0% of MCTD patients. Pulmonary hypertension was a rare finding as seen
only in 1 RA patient (3.4%). Seven out of 16 (43.8%) CTD patients with
radiographic lesions and 15 out of 28 (53.6%) CTD patients with abnormal PFTs
were asymptomatic. There was a significant association between pleuropulmonary
involvement and methotrexate use, (p=0.046), and corticosteroid use (p=0.033). 1.5 Conclusion: One third of CTDs
patients have clinical involvement. Half of the asymptomatic patients have
radiographic and/or PFTs abnormalities. CTDs should be systematically screened
for pulmonary involvement. 2. Keywords: Africa; Connective Tissue Disorders; Pleuropulmonary
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