Protective Role of Wheat Germ and Grape Seed Oils in Chlorpyrifos-Induced Oxidative Stress, Biochemical and Histological Alterations in Liver of Rats

The purpose of the present study was to assess the antioxidant role of wheat germ oil (WGO) and grape seed oil (GSO) in chlorpyrifos-induced oxidative stress, biochemical and histological changes in liver in male albino rats. Chlorpyrifos (CPF) was added to the different experimental tested diets at two levels of low and high doses (25 and 50 mg/kg diet respectively). WGO and GSO were added to the experimental diets at a level of 200 mg/kg diet. The results showed that the enzyme activities such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (γGT) were significantly increased in rats administrated only by chlorpyrifos, while total proteins, albumin, and globulin showed a significant decrease at high and low doses of CPF groups. In addition, CPF caused a significant decrease in the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione- s-transferase (GST).Wheat germ oil and grape seed oil supplementation caused significant improvement in different biochemical parameters of all rat groups.