Влияние лечебного плазмафереза в комплексе неоадъвантной полихимиотерапии на окислительный метаболизм эритроцитов и состояние их мембран у больных распространенным раком яичников

The results of a comparative study of malondialdehyde (MDA) content, activity of antioxidant enzymes and indicators characterizing structural and functional state of membranes of erythrocytes in patients having advanced ovarian cancer (OC), who underwent therapeutic plasmapheresis before neoadjuvant polychemotherapy (PCT), and in patients with OC treated with chemotherapy treatment only, were presented. Oxidative stress and erythrocyte membrane fluidity increased on the second day after PCT in patients with OC treated with chemotherapy treatment only; redox processes decreased and dysfunction of erythrocyte membranes intensified one month after PCT. Plasmapheresis inclusion into the complex of cancer treatment contributed to the decrease of lipid peroxidation level, improvement of antioxidant defense in erythrocytes, stabilization of membranes of red blood cells on the second day after PCT and normalization of most of the studied parameters up to the level of healthy donors one month after the treatment.