15, 16-methylene-17-hydroxy-19-nor-21-carboxylic acid y-lactone steroid derivative, the use thereof and the derivative drug

The invention relates to 15,16-methylene-17-hydroxy-19-nor-21-carboxylic acid γ-lactone steriod derivative having the general chemical formula I, wherein R The invention also relates to the use of these derivatives for the preparation of a medicament for oral contraception and for the treatment of pre-, peri- and post-menopausal disorders, and to pharmaceutical compositions containing such derivatives. The derivatives of the invention exhibit progestational and in preferred cases, also an antimineralocorticoid and neutral to slightly androgenic effect.