Hepatotoxicity Related to Paraquat and Diquat Absorption Through Intact Skin

Paraquat and diquat are among the most used herbicides worldwide. Both are bipyridyl herbicides associated with frequent household or professional accidental exposition and toxicity [1]. Dermal absorption of paraquat is scarce with intact skin (0.3%) but cases of severe toxicity have been observed in subjects with extensive skin damage [2–4]. Paraquat-induced liver toxicity has been described less frequently than lung or kidney toxicity. Centrolobular necrosis and proliferation of Kupffer cells and bile ducts have been