Safety and Immune Effect of TCND Vaccine on Young Chickens

Safety and immune effect of TCND vaccine, which was established by BANKOWSKI and produced by Eli Lilly & Co., were studied on young chickens.Results obtained were as follows:1. TCND vaccine was moderately pathogenic against young chicks under 3 days of age.2. The vaccine was effective on most chicks free from passive antibody. It was not so, however, on chicks having maternal antibody.3. Rise of antibody titer of birds by using the vaccine was compared with that by a B1-strain vaccine and with that by a killed vaccine. Though HI antibody titer by TCND vaccine was lower than by the others, neutralization antibody titer of the TCND group was similar among chicken groups with respective vaccination.4. Relatively high immune effect was obtained in chickens inoculated with the vaccine through intramusclar, intravenous and wing-web routs, but none by oral and eye-dropping administration.