Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model

Weirong Wang,Thomas S. McIntosh,Xiling Jiang,Rajitha Doddareddy,Elayne C. Dell,Honghui Zhou

Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model

2016

Weirong Wang
Thomas S. McIntosh
Xiling Jiang
Rajitha Doddareddy
Elayne C. Dell
Honghui Zhou

Purpose Study the disposition and target-neutralization capability of an anti-interleukin-6 (IL-6) monoclonal antibody (mAb) at the joint in a mouse collagen-induced arthritis (CIA) model.

Keywords:

In vivo
Immunology
Arthritis
Chemistry
Monoclonal antibody
Pharmacokinetics
Collagen-induced arthritis
Disposition
site of action
Biochemistry
pharmacology toxicology
Pharmacology
target engagement
Molecular biology
tissue distribution

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