A Novel Ergot Alkaloid as a 5-HT1A Inhibitor Produced by Dicyma sp.

In the course of a search for small-molecule inhibitors of 5-hydroxytryptamine receptors we have identified a novel ergoline derivative (1) from the fungal culture of Dicyma sp. This compound has a pKi of 10.2 versus the 5-hydroxytryptamine1A receptor subtype. The structure was elucidated by extensive NMR spectroscopy and mass spectrometry.