Tu1044 Soluble CD14 are a Useful Hallmark of Liver Inflammation and Predictor for Progression of Fibrosis in NASH

low and high density lipids, vitamin D; 3. demographic/clinical information including age, gender, ethnicity, income, smoking history, and frequency of exercise; diagnoses: hypertension (HTN), diabetes mellitus (DM). Statistical analyses were conducted with SUDAAN 10.0. RESULTS: A total of 9,217 adult NHANES III participants were included of whom 2,325 had NAFLD and 6,892 were non-NAFLD controls. NAFLD was independently associated with older age, male gender, Hispanic ethnicity, BMI, DM, hypertension and dyslipidemia. Anthropometric measurements correlated strongly with each other and were also independently associated with risk of NAFLD (P<0.01). Only metabolic conditions were found to be associated with overall mortality in NAFLD. Furthermore, the diagnosis of NAFLD and body fat (%) were independently associated with liver-related mortality (P=0.02). Body fat percentage was also found to be associated with higher risk of liver-related mortality among women (aHR=1.06, 95% CI: 1.03-1.09). CONCLUSIONS: Clinical measures of obesity including %BF are independently associated with the diagnosis of NAFLD and with liverspecific related mortality among individuals with NAFLD.