Clinical features and CT signs of early familyclustering corona virus disease 2019/ 家庭聚集性早期新型冠状病毒肺炎的临床与CT表现初步探讨

ABSTRACT: Objective To investigate the temporal variation of the clinical symptoms, nucleic acid detection and CT characteristics of corona virus disease 2019(COVID-19) patients with clustered onset in families Methods We made a retrospective analysis of the COVID-19 patients (4 males and 3 females) with clustered onset in 3families diagnosed in The First Affiliated Hospital of Xi' an Jiaotong University from January 27 to February 1,2020 We analyzed the clinical data and CT findings Results The CT signs in the three groups of families were consistent with early manifestations: multiple ground-glass opacity (GGO), under the pleura in both lungs, with or without thickening of small pulmonary vessels In the first group, two people were confirmed with positive nucleic acid in the first diagnosis The wife was asymptomatic, but the CT finding was positive Her husband was symptomatic, and the first CT result was negative, but the CT was positive two days later In the second group, the spouses had the onset at the same time, and both CT and nucleic acid were positive In the third group, all the three people had the onset at the same time, and the CT results were all positive, but the son was diagnosed only after the third nucleic acid test, and the other two were positive at the first diagnosis Conclusion There are time differences in clinical symptoms, nucleic acid detection, and CT manifestations of COVID-19 in the early stage These differences may be an important underlying factor for the spread of the disease Correct understanding of the differences is beneficial to early blocking of the transmission pathways of crowd aggregation