The Role of P-Glycoprotein Expression on Absorption and Distribution of HIV-1 Protease Inhibitors
2010
OBJECTIVE By introducing the efflux function of P-glycoprotein(P-gp),the way to optimize the treatment of HIV-1 infection by modulation of P-gp was discussed.METHODS Searching and summarizing literatures about HIV-1 protease inhibitor and P-gp.RESULTS The effect of P-gp expression for HIV-1 protease inhibitor absorption and distribution was summarized.CONCLUSION P-gp can hamper the absorption and distribution of HIV-1 protease inhibitor.The therapeutic effect of HIV-1 protease inhibitors can be improved by modulating P-gp properly,however,the selection and use of P-gp inhibitor will be an arduous mission in the future.
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