Label free optical cell and tissue characterization for veterinary pathology and teratology (Conference Presentation)

The pathological examination of regulatory relevant tissue samples is done manually and highly time consuming. Label free optical technologies like quantitative phase microscopy (QPM) and Optical Coherence Tomography (OCT) provide fast analysis of fixated cells and tissues by biophysical parameters. Combination of various wavelengths allows label free QPM tissue characterization equivalent to HE staining. Recent OCT studies showed 3D imaging of rat embryo details as bone structures, full vertebra, whole feet and parts of the skull. The multi-functional potential of QPM and OCT represents a promising new approach for label free phenotyping of regulatory relevant cell and tissue alterations.