Laboratory indicators in drug addicts and tertiary prevention of narcotic dependence

BACKGROUND: The authors report on some laboratory indicators in opiate abusers dependent for prolonged periods on opiates. The objective of the study is a proposal for an examination pattern in adepts during oral substitution therapy and emphasis on the necessity of systematic follow up of the health status. METHODS AND RESULTS: In 27 opiate abusers with a varying period of dependence on opiates the hematology laboratory tests was assessed, plasma levels of some minerals, renal and hepatic functions, some enzymes and metabolic indicators and vitamin D metabolites. For statistical evaluation Student's t-test was used and simultaneous testing. CONCLUSIONS: Long-term opiate abuse damages in 30 and 35% resp. liver functions. Therefore vitamin D deficiency develops. The authors recommend to follow up the health status of opiate abusers during oral substitution treatment (tertiary prevention).