The Prodrome and Clinical Risk for Psychotic Disorders

Significant progress has been made in the characterization of CHR syndromes, and findings indicate that they are associated with milder versions of many psychological deficits and biological abnormalities observed in psychotic disorders. Moreover, those at CHR who manifest the most severe deficits and abnormalities seem to be at greatest risk for psychosis conversion. Findings indicating prodromal changes in brain structure suggest that this stage is characterized by neuroplasticity that can provide leverage for preventive intervention. Although a level of scientific understanding that supports specific interventions has not yet been reached, the present trajectory of research progress holds promise for the future. One of the main goals of ongoing research is development of better prediction algorithms with the goal of attaining levels of positive predictive power that can justify delivery of preventive interventions in clinical trials.