HUMAN MEGAKARYOCYTOPOI ESIS

The study of human megakaryocytopoi esis has grown tremendously in the past decade. Numerous advances and improvements in methodologies have contributed to a much enhanced understanding of the developmental biology of this platelet-produci ng cell. This chapter reviews these meth­ odologies, discusses current concepts regarding the regulation of human megakaryocyte devciopment, and alludes to the clinical significance of