Deletion of major non essential genomic regions in the vaccinia virus Lister strain enhances attenuation without altering vaccine efficacy in mice Running title: Attenuation and vaccination with VACV Lister mutants

word count: 250 Text word count: 6326 without references (2835), figures and legends (773) and tables (774) Corresponding authors : JMC : Unite de Virologie, IRBA, 24 Avenue des Maquis du Gresivaudan, La Tronche, France ; e-mail : jmcrance@crssa.net; tel : (33) 4 76 63 69 16 RD : IGBMC 1 rue Laurent Fries, BP10142, Illkirch, 67404, France ; e-mail : drillien@igbmc.fr; tel : (33) 3 88 65 57 46 Present address: Vivalis, 6 rue Alain Bombard, Saint-Herblain, 44800, Nantes, France Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.02359-10 JVI Accepts, published online ahead of print on 2 March 2011