PHARMACOLOGICAL PROPERTIES OF SCHIFF BASE METAL COMPLEXES DERIVED FROM SUBSITUTED PYRIDINE AND AROMATIC AMINE - A REVIEW

Schiff bases are aldehyde or ketone like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. Aromatic aldehydes and aliphatic or aromatic ketone gives stable azomethine moiety. So far, modifications of the Schiff bases have proven highly efficient with improved potency and lesser toxicity. Schiff base metal(II) complexes of various donor atom of Substituted pyridine and aromatic amine based ligands posses anti-tumor and anti-viral, anti -malarial, anti -fungal and anti microbial activities. This review focuses on pharmacological properties of Schiff base metal(II) complexes derived from Substituted pyridine and aromatic amine.