IgE Sensitization to Aspergillus fumigatus Is Not a Bystander Phenomenon in Cystic Fibrosis Lung Disease

cantly impaired lung function parameters in Af-sensitized compared with Af-nonsensitized patients, with an average diff erence in FEV 1 of 19 4% predicted. In a multivariate analysis with age, sex, BMI, Pseudomonas aeruginosa colonization, pancreatic insuffi ciency, and gastroesophageal refl ux disease as covariates, a signifi cantly lower FEV 1 and vital capacity ( P , .001) was associated with Af sensitization, as well as an increased airway resistance ( P , .05) and hyperinfl ation (higher residual volume, P , .001) (e-Table 1). Interestingly, no signifi cant diff erences in lung function parameters were found between patients with serologic criteria for allergic bronchopulmonary aspergillosis (ABPA) (n 5 17) and patients with sensitization to Af without ABPA. Similar to the data presented by Baxter et al 1 and others, 3 we observed, in a 3-year period, more exacer