Enhanced performance of a metal-organic framework analogue to MIL-101(Cr) containing amine groups for ibuprofen and nimesulide controlled release

Abstract In order to improve the interaction of MIL-101(Cr) with ibuprofen (IBU) and nimesulide (NMS), its functionalization with NH 2 groups was proposed. MIL-101(Cr) showed a good loading capacity of IBU and NMS (850 and 443 mg g − 1 , respectively) and released 80% of IBU and 10% and NMS after 8 days. The 10% NH 2 -MIL-101(Cr) showed a higher loading capacity than MIL-101(Cr) (900 mg g − 1 for IBU and 563 mg g − 1 for NMS) and released lower amounts of IBU (70%) after 6 days and NMS (8%) after 8 days. The results show that the functionalization with NH 2 groups improves the interactions between the materials and the drugs, which is of interest in the development of new controlled drug release devices.