Reductive N-methylation of quinolines with paraformaldehyde and H2 for sustainable synthesis of N-methyl tetrahydroquinolines
2019
A new and straightforward method was developed for the synthesis of N-methyl-1,2,3,4-tetrahydroquinolines by one-pot reductive N-methylation of quinolines with paraformaldehyde and H2 over Pd/C catalyst. A series of functional MTHQs, including (±)-galipinine and (±)-angustrureine were successfully synthesized in good to excellent yields by applying this simple catalyst system.
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