A personalized blood glucose level prediction model with a fine-tuning strategy: A proof-of-concept study.

Abstract Background and Objective: The accurate prediction of blood glucose (BG) level is still a challenge for diabetes management. This is due to various factors such as diet, personal physiological characteristics, stress, and activities influence changes in BG level. To develop an accurate BG level predictive model, we propose a personalized model based on a convolutional neural network (CNN) with a fine-tuning strategy. Methods We utilized continuous glucose monitoring (CGM) datasets from 1,052 professional CGM sessions and split them into three groups according to type 1, type 2, and gestational diabetes mellitus (T1DM, T2DM, and GDM, respectively). During the preprocessing, only CGM data points were utilized, and future BG levels of four different prediction horizons (PHs, 15-min, 30-min, 45-min, and 60-min) were used as output. In training, we trained a general CNN and a multi-output random forest regressor using a hold-out method for each group. Next, we developed two personalized models: 1) by fine-tuning the general CNN on partial sample points of each CGM dataset, and 2) by learning a CNN from scratch on the points. Results For all groups, the fine-tuned CNN showed the lowest average root mean squared error, average mean absolute percentage error, highest average time gain (PH = 15 and 60 min in T1DM) and highest percentage in region A of Clarke error grid analysis at all PHs. In the performance comparison between the fine-tuned CNN and other models, we found that the fine-tuned CNN improved the performance of the general CNN in most cases and outperformed the scratch CNN at all PHs in all groups, making the fine-tuning strategy was useful for accurate BG level prediction. We analyzed all cases of four predictive patterns in each group, and found that the input BG level trend and the BG level at the time of prediction were related to the future BG level trend. Conclusions We demonstrated the efficacy of the fine-tuning method in a large number of CGM datasets and analyzed the four predictive patterns. Therefore, we believe that the proposed method will significantly contribute to the development of an accurate personalized model and the analysis for its predictions.