Cu(II) and Ni (II) coordination polymers: magnetic properties and protective activity on Parkinson disease

Two novel transition metal coordination polymers on the basis of azide {[Cu2(bpym)(N3)4] MeCN}n (1) and [Ni(bpym)(N3)2]n (2) were generated through utilizing 5,5′-bipyrimidine (bpym), a kind of semi-flexible tetrahedral nitrogen-donor ligand, with the approach of slow volatilization, and their structures were characterized via the thermogravimetric analyses, the single crystal X-ray diffraction, elemental analysis (EA), powder X-ray diffraction (PXRD) and infrared spectroscopy (IR). The magnetic properties for the prepared two compounds reveal that the antiferromagnetic coupling is existed in consecutive metal ions. Next, the two compounds’ evaluation of application values on Parkinson's disease (PD) was performed and the corresponding mechanism was assessed simultaneously. At first, the N-methyl-D-aspartic acid (NMDA) receptor relative expression levels against neurons were tested via Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Besides, the Annexin V-FITC/PI apoptosis assay was implemented and the levels of apoptotic dopaminergic neuron was measured after the treatment of compound.