Inhibition of Formation of Calcium Phosphate Deposits on Teeth and Dental Materials: Recent Advances

The inorganic composition of dental calculi from teeth and dentures has been characterized by x-ray diffraction, electron microprobe, and infrared absorption spectroscopy. They consist of carbonated hydroxylapatite (CHA), dicalcium phosphate dihydrate (DCPD), octacalcium phosphate (OCP), and magnesium-substituted beta-tricalcium phosphate (6-TCMP). The calculi on denture surfaces are principally CHA. Formulations have been developed to inhibit formation of these calculi in humans. The active inhibitors are pyrophosphate, pyrophosphate plus polymer, and zinc salts. These agents inhibit calculus formation in humans by preventing the formation of hydroxyapatite crystals. The new formulations include multiple-benefits products containing fluoride and antimicrobial and/or desensitizing agents. These provide not only reduction in calculus formation in humans but also reduced plaque, gingivitis, and/or dentinal hypersensitivity. Recent studies have also indicated a relationship between gingival recession and sup...