Effect of heat in treatment of bone disease and bone regeneration and process of repair.

How to use physic agent of heat in treatment bone diseases and in repair bone defect and how to be affected the osteoblast by heat have been proved gradually.Invariably heat treatment can promote osteoblast differentiation and the heat shock protein and the heat shock factors participate in cellular protection.The influence of the heat for the relationship of osteoblast and osteoclast and the regulatory mechanism of HSP70 and HSF2 for the RANKL of osteoblast has been not interpreted thoroughly.To find out the influence and the regulatory mechanism can reveal the key point of heat how to interfere in bone transformation.