4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

Anthony J. Cocuzza,Frank Worden Hobbs,Charles R. Arnold,Dennis R. Chidester,Jerry A. Yarem,Steven Culp,Lawrence W. Fitzgerald,Paul J. Gilligan

4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

1999

Anthony J. Cocuzza
Frank Worden Hobbs
Charles R. Arnold
Dennis R. Chidester
Jerry A. Yarem
Steven Culp
Lawrence W. Fitzgerald
Paul J. Gilligan

A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.

Keywords:

Organic chemistry
Hormone
Aryl
Corticotropin-releasing hormone
Ligand (biochemistry)
Biochemistry
Chemistry
Chemical synthesis
Antagonist
In vitro
Stereochemistry
Cell culture

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations