Inhibitory effects of Injinseulki on Chemical-induced hepatic fibrosis in Rats

The inhibitory effects of Injinseulki including extracts of melanian snail plus phytomedicinal plants on -induced fibrosis, plus LPS-induced production of NO, PMA-stimulated production , and tacrine-induced hepatic injury were investigated in rats, RAW 264.7 or HepG2 cells. The ethanol extracts of melanian snail significantly inhibited tarcrine-induced inury of HepG2 cells. Injinseulki inhibited the production of NO and in a dose-dependent manner in activated RAW 264.7 macrophages. Injinseulki significantly inhibited chemical-induced fibrosis in Rats. These results show that Injinseulki including extracts of melanian snail plus phytomedicinal plants may explain some known biological activities of Injinseulki including their anti-inflammatory and anti-fibrotic effect, and is of considerable benefit in the treatment for live diseases.