5-(4-nitrophenyl)-3-hydroxylisoxazole and preparation process and use thereof

2014 
The invention relates to 5-(4-nitrophenyl)-3-hydroxylisoxazole and a preparation process and use thereof. The preparation process comprises the following steps: 1) by taking 4-nitrobenzaldehyde, triphenyl phosphine and ethyl chloroformate as initial raw materials, generating corresponding 3-(4-nitrophenyl) ethyl acrylate by Witting reaction; 2) carrying out additive reaction on 3-(4-nitrophenyl) ethyl acrylate and bromine to generate corresponding ethyl 3-(4-nitrophenyl)-2, 3-dibromo propionate; and 3) carrying out reaction on ethyl 3-(4-nitrophenyl)-2, 3-dibromo propionate and hydroxylamine hydrochloride under the effect of sodium hydroxide to close the ring to generate corresponding 5-aryl-3-hydroxylisoxazole. The 5-(4-nitrophenyl)-3-hydroxylisoxazole provided by the invention has the beneficial effects that the 5-(4-nitrophenyl)-3-hydroxylisoxazole can be developed as an insecticide and has a wide application prospect.
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