Thromboelastometry (Tem) in Pregnant Women: Basal Tem Profile and Tem Profile after Carbetocin Administration in Women at High Risk for Post-Partum Haemorrhage

The aims of this study were to evaluate the thromboelastometry profile in pregnant at risk of post-partum haemorrhage and evaluate changes in thromboelastometry profile after administration of Carbetocin, used as uterotonic drugs in this patients during caesarean section. Twenty-one women undergoing elective caesarean section were consecutively enrolled, with risk factors for primary post-partum haemorrhage. All patients underwent the same combined spinal-epidural (CSE) anaesthesia. A basal thromboelastometry profile was performed. Women according to the study protocol received 500 ml of 0.9% NaCl solution IV and as uterotonic drug a bolus of 100 μg IV of Carbetocin at delivery of the anterior shoulder. Five minutes after uterotonic infusion, a new blood sample was performed for thromboelastometry profile after Carbetocin. Considering the changes in thomboelastometry profile before and after Carbeton, TEM exhibited significantly lower in MCF (in-TEM and ex-TEM) (p<0.01) and in A10 (in-TEM and ex-TEM) (p<0.01). We note also a significantly higher CFT ex-TEM value after Carbetocin (p<0.01).