Erectile Dysfunction Is More Common in Young to Middle‐Aged HIV‐Infected Men than in HIV‐Uninfected Men

ABSTRACT Introduction Erectile dysfunction (ED) is common among elderly men and patients suffering from chronic diseases, the latter probably including also HIV infection. No studies, however, compared the prevalence of ED in HIV‐infected and HIV‐uninfected individuals using the International Index of Erectile Function (IIEF‐15). Aim The aim of this study is to compare ED prevalence in young to middle‐aged men with and without HIV infection using the IIEF‐15 questionnaire. Methods We conducted a cross‐sectional, observational, controlled study on 444 HIV‐infected men and 71 HIV‐uninfected men. Main Outcomes Measures The IIEF‐15 questionnaire was used to assess ED. A cutoff score of ≤25 of the erectile domain was used to diagnose ED. Serum testosterone, demographic, and anthropometric (weight, height, and body mass index [BMI]) characteristics were obtained from all participants. Statistics included the T ‐test, the Fisher's test, univariable and multivariable logistic regression, and univariate and multivariate Spearman's correlation analysis. Results The HIV‐uninfected group was significantly younger than the HIV‐infected group and presented a higher BMI ( P P P Conclusions This study demonstrates a clear association between ED and HIV infection, after adjusting for age and BMI. Other than HIV infection, hypogonadism was associated with ED. In addition, the prevalence of ED was higher in HIV‐infected men than in HIV‐uninfected men, in all decades of age. The early onset of ED in HIV‐infected men could be considered a peculiar clinical hallmark of HIV and confirms precocious aging in these patients. ED should be of concern to clinicians when managing HIV‐infected men even if the latter are young or middle aged. Zona S, Guaraldi G, Luzi K, Beggi M, Santi D, Stentarelli C, Madeo B, and Rochira V. Erectile dysfunction is more common in young, middle‐aged HIV‐infected men than in HIV‐uninfected men. J Sex Med 2012;9:1940–1947.