Fluorescence and Release Property Research of a New Fan-shape Polyamidoamine Dendrimer with a Core of Glycin

Dendrimers are highly branched,monodisperse macromolecules with a well-defined three-dimensional structure.Since their introduction in the mid-1980s,this novel class of polymeric materials has attracted considerable attention.Dendrimers differ from many classical polymers,such as linear and branched polymers,in that they are well-defined,with the perfectly branched dendritic architecture and a high degree of molecular uniformity,as well as a highly functional surface.This unique properties have hence been validated in a substantial amount of different application fields in recent years.For example,as carriers for the development of drug delivery systems、gene delivery and medical treatment.So it is very important to synthesize a new denerimers because of their potential applications.Nowadays,the synthesis of polyamidoamine denerimers includes " solid phase synthesis" and "liquid phase synthesis".A new thought of synthesis polyamidoamine denerimer by fall together this two advantage is introduced.Having glycin as the core,a new fan-shape polyamidoamine denerimers are synthesized.The Release Property are being studied too.The dendrimer were then reacted with 1- acetic-5-fluorouracil to form dendrimer- 5FU conjugates.Hydrolysis of the conjugates in a phosphate buffer solution(pH7.4) at 37℃ will release free 5FU.The dendrimer seems to be a promising carrier for the controlled release of anti-tumor drugs.