Altered Disposition and Effect of Lerisetron in Rats with Elevated Alpha1-acid Glycoprotein Levels

Nerea Jauregizar,R. Calvo,Elena Suarez,Antonio Quintana,Ewa Raczka,John C. Lukas

Altered Disposition and Effect of Lerisetron in Rats with Elevated Alpha1-acid Glycoprotein Levels

2001

Nerea Jauregizar
R. Calvo
Elena Suarez
Antonio Quintana
Ewa Raczka
John C. Lukas

Purpose. To examine the effect of changes in plasma α1-acid glycoprotein (AAG) levels on the pharmacokinetics (PK) and pharmacodynamics (PD) of lerisetron, a novel serotonin 5-HT3 receptor antagonist, in the rat.

Keywords:

Receptor antagonist
Pharmacodynamics
Serotonin
Catecholamine
Biochemistry
Glycoprotein
Lerisetron
Endocrinology
Chemistry
Pharmacokinetics
Disposition
Internal medicine
Blood plasma
Pharmacology
Antagonist

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