Эффективность применения витаминных комплексов в виде мармеладных пастилок у здоровых детей и детей с аллергическими заболеваниями дошкольного и школьного возраста

Background . Vitamins and minerals are significant components of the diet of a person of any age. Nowadays, when there is a focus on the ‘Western’ type of food, it is impossible to get the necessary amount of all vitamins and minerals with a normal diet, which explains the high prevalence of hypovitaminosis in children. It is known that children with allergic diseases have a lower provision of vitamins as compared to apparently healthy children, which is the rationale for the relevance of this study. Our aim was to evaluate the efficacy and tolerability of vitamin complexes in children, including children with allergic reactions. Patients and Methods . The work was performed at the Federal State Autonomous Institution ‘NMRC for Children’s Health’ of the Ministry of Healthcare of Russia from February to August 2017. We examined 90 apparently healthy children without severe somatic pathology at the age of 4–14 years, including 17 children with a history of allergic reactions. The children were divided into 2 groups. Group 1 received marmalade pastilles with vitamins C (16–27% of the recommended dietary allowance, RDA), E (29–40% of the RDA), A (24–34% of the RDA), B5 (40–80% of the RDA) , B9 (18–35% of the RDA), and D3 (4–9% of the RDA). Group 2 received marmalade pastilles with vitamins C (57–80% of the RDA), E (50–86% of the RDA), A (40–80% of the RDA), B5 (143–167% of the RDA), B3 (44 –73% of the RDA), D3 (10% of the RDA), B6 (82–117% of the RDA), and B12 (83–167% of the RDA). The tolerance of the vitamin complex was evaluated by the questionnaire method. The provision of vitamins C and B6 was evaluated in 39 children by an hourly urinary excretion of vitamins at the beginning of the study before taking the vitamin complex and 1 month after the start of intake. Results . The studied vitamin complexes showed good clinical tolerance in all children, including those with a history of allergic reactions to vitamin-mineral complexes. Evaluation of the efficacy of the vitamin complex in the 2nd group showed an improved provision, especially in children who had a deep deficiency of vitamins C (10%) and B6 (22%). At the same time, the excretion of vitamin B6 metabolite increased by 42.2%. Conclusion . The study showed the effective absorption of the studied vitamins and the good tolerability of the used vitamin complexes, including children with a history of allergic reactions to vitamin-mineral complexes.