Two-component systems of Mycobacterium tuberculosis: structure-based approaches.

Abstract Mycobacterium tuberculosis contains few two‐component systems compared to many other bacteria, possibly because it has more serine/threonine signaling pathways. Even so, these two‐component systems appear to play an important role in early intracellular survival of the pathogen as well as in aspects of virulence. In this chapter, we discuss what has been learned about the mycobacterial two‐component systems, with particular emphasis on knowledge gained from structural genomics projects.