A longitudinal study of natural antibody development to pneumococcal surface protein A families 1 and 2 in Papua New Guinean Highland children: a cohort study

Jacinta Francis,Peter Richmond,Audrey Michael,Peter Siba,Peter Jacoby,Belinda J. Hales,Wayne R. Thomas,Deborah Lehmann,William Pomat,Anita H. J. van den Biggelaar

A longitudinal study of natural antibody development to pneumococcal surface protein A families 1 and 2 in Papua New Guinean Highland children: a cohort study

2016

Jacinta Francis
Peter Richmond
Audrey Michael
Peter Siba
Peter Jacoby
Belinda J. Hales
Wayne R. Thomas
Deborah Lehmann
William Pomat
Anita H. J. van den Biggelaar

Background Pneumococcal surface protein A (PspA), a conserved virulence factor essential for Streptococcus pneumoniae attachment to upper respiratory tract (URT) epithelia, is a potential vaccine candidate for preventing colonisation.

Keywords:

Antibody
Respiratory tract
Innate immune system
Streptococcus pneumoniae
Microbiology
Cohort study
Immunology
Colonisation
Virulence factor
Longitudinal study
Biology
Papua New Guinean
Pneumococcal surface protein A

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