Complications of long-term therapy for ANCA-associated systemic vasculitis.

Antineutrophil cytoplasmic antibody-associated systemic vasculitides (AASVs) are a group of inflammatory disorders that largely affect the pulmonary and renal vascular beds. Although the advent of effective immunosuppressive therapies has markedly improved patient survival, current immunosuppressive therapies used for AASV incur substantial short-term and long-term toxic effects. This Review outlines currently recommended treatment options for AASV and describes the long-term adverse effects of immunosuppression along with strategies for prophylaxis and monitoring.