AB0717 Clinical Characteristics of Ankylosing Spondyloarthritis in Real Clinical Practice in Russia: Results of A Single Multicenter Non-Interventional Study – Epika 2

Objectives Recognizing the clinical picture of ankylosing spondylitis (AS) in real practice would help to optimize healthcare services provided to this group of pts. Methods A single multicenter non-interventional study was conducted in spring 2015 y in order to ascertain the clinical features of AS in the real practice of a rheumatologist. 402 consecutive AS pts (meeting modified N-Y criteria) referred to a rheumatologist were evaluated following accepted standards during 2 mo at 10 clinical centers of Russia. All pts were evaluated, including those who addressed because of deterioration, and pts coming for regular check-ups within the disease monitoring. Results Patients9 mean age was 40,8±11,5 y,. 292 (72,6%)- males, 82,6% were HLA-B27- positive. Age at AS onset was 27,6±12,3 y., in 65,4% AS onset occurred before the age of 30 y.o., and in 16,9% – before 16 y.o. Time to establishing the AS diagnosis was 85,2±86,2 mo. By the moment of evaluation inflammatory back pain was present in 55,7% pts, peripheral arthritis - in 33,1%, enthesitis – in 37,1%, dactylitis – in 1,2%. Average BASDAI disease activity score was 4,3±2,1 (in 54,2% of pts it was >4, in 12,7% - >7, and in 18,2% - 4,in 17,1%,- >7, and in 26,1% - Conclusions In real clinical practice the final AS diagnosis is usually established in more than 7 years after AS onset, by that moment the disease has already reached high activity and pronounced functional impairments occurred. Various comorbidities are found in >40% of AS pts, but with much lower incidence as compared to other systemic rheumatoid diseases. Disclosure of Interest None declared