Mechanism of Pd-catalysed C(sp3)–H arylation of thioethers with Ag(I) additives

Mechanistic studies reveal that Pd-catalyzed C(sp3)–H arylation of thioethers with silver(I) additives takes place via C(sp3)–H activation, oxidative addition and reductive elimination, wherein all steps proceed via the heterodimeric Pd–Ag pathway. Besides, the active heterodimeric Pd–Ag species are detected by mass spectrometry via control experiments.