Synthesis and Immunotropic Activity of New Quinazoline Derivatives in Mice

New condensed pyrimidine compounds with a benzoannelated quinazoline structure and various functional substituents at the pyrimidine N3-position were synthesized and included 2-methyl-3-(2-phenyl-2-oxoethyl) quinazolin-4(3H)-one; 3-(2-tert-butyl-2-oxoethyl)quinazolin-4(3H)-one; 3-[2-(1-naphthyl)-2-oxoethyl]-6-bromoquinazolin-4(3H)-one; 3-(2-isopropyloxy-2-oxoethyl)quinazolin-4(3H)-one; and 3-{2-[(4,6-dimethylpyrimidin- 2-yl)amino]-2-oxoethyl}quinazolin-4(3H)-one. The new quinazoline derivatives were found to produce a corrective action on proliferation processes in immunocompetent organs as manifested by restoration of the number of splenocytes and thymocytes on the background of cyclophosphan-induced immunosuppression in CBA mice of both sexes aged 3 – 4 months.