Synthesis of 2-Substituted-1 H-Benzo(d)Imidazoles through Oxidative Cyclization of O-Phenylenediamine and Substituted Aldehydes using Dioxane Dibromide.

Benzimidazole ring is a useful synthon in medicinal chemistry and is a part of many biologically active compounds. This communication reports a mild and efficient approach for the synthesis of benzimidazole ring through oxidative cyclization of o-phenylenediamine and different aldehydes using dioxane dibromide, as a user-friendly reagent. This is a new, convenient and facile methodology for the synthesis of 2-substituted-1H