Quinazoline-N-phenethyl tetrahydroisoquinoline compound and preparation method and application thereof

The invention relates to compounds shown as a general formula (I) and salt thereof. The compounds have strong reverse tumor multidrug resistance (MDR) effect, activity of part of the compounds is far higher than verapamil, and the compounds have low cytotoxicity. The invention further relates to a medicinal preparation containing the compounds. A series of the compounds shown as the general formula (I) and the pharmaceutically acceptable salt thereof are synthesized.