Base derivative of tetrandrine and its preparation method and application in the preparation of antineoplastic

The present invention discloses a tetrandrine derivatives and preparation method thereof having anti-tumor activity of the compound of structural formula: The method is bis-benzyl isoquinoline compounds as raw materials, is dissolved in a certain solvent, adding the reaction was Y, mixed, at -20 ℃ ~ 300 ℃, under neutral or basic conditions, the reaction 0.1h ~ 72h, and was added to the acid solution after the reaction, and then after separation and purification to obtain the desired product. Tetrandrine derivative obtained by the present invention for the preparation of human hepatoma cell line HepG2 and HT29 human colon cancer cell proliferation better inhibition, can be used for the preparation of antineoplastic drugs.