Oxidative Stress Mediates Protein Kinase C Activation and Advanced Glycation End Product Formation in a Mesangial Cell Model of Diabetes and High Protein Diet

Katherine R. Tuttle,Robert J. Anderberg,Sheryl K. Cooney,Rick L. Meek

Oxidative Stress Mediates Protein Kinase C Activation and Advanced Glycation End Product Formation in a Mesangial Cell Model of Diabetes and High Protein Diet

2009

Katherine R. Tuttle
Robert J. Anderberg
Sheryl K. Cooney
Rick L. Meek

Background/Aims: High levels of glucose and/or amino acids increase advanced glycation end products (AGE) and activate protein kinase C (PKC), a key signal for injury in mesangial c

Keywords:

Glycation
Advanced glycation end-product
Protein kinase C
Oxidative stress
Endocrinology
Activator (genetics)
Amino acid
Mesangial cell
NADPH oxidase
Medicine
Biochemistry
Internal medicine
High-protein diet
Reactive oxygen species

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