1544-P: High Risk of Adverse Drug Reaction (ADR) in Older Adults with Type 1 Diabetes (T1D)

The three most common drugs with high risk of ADR in older adults are insulin, anticoagulants, and opioids. As all older adults with T1D are already on insulin, we evaluated how frequently they were on other medications with high risk of ADR. In addition we assessed age-related factors associated with poor outcomes including hypoglycemia risk, and compared with younger cohort with T1D. Methods: The T1D Exchange Clinic network database was used to evaluate older≥65 years) adults with T1D and compare them with younger (18-35 years) cohort on and frequency of severe hypoglycemia (SH) within prior 3 month, ED visit for SH and use of anticoagulants, opiates drugs. Results: We analyzed data from 569 older (72±5 years) and 2835 younger (23±5 years) adults with T1D. The results are shown in the Table. Overall 8% of older adults had fall within past 6 months, and 11% had an episode of lost consciousness. Conclusion: Older adults with T1D are vulnerable to ADR due to polypharmacy. The risk of poor outcomes is exacerbated by presence of multiple comorbidities, higher hypoglycemia unawareness, and greater number of severe hypoglycemia ep Conclusion: Older adults with T1D are vulnerable to ADR due to polypharmacy. The risk of poor outcomes is exacerbated by presence of multiple comorbidities, higher hypoglycemia unawareness, and greater number of severe hypoglycemia episodes. Disclosure E. Toschi: Advisory Panel; Self; Lexicon Pharmaceuticals, Inc. C. Slyne: None. A. Atakov-Castillo: None. K. Sifre: None. A.B. Dufour: None. S. Carl: None. J. Greenberg: None. M. Munshi: Consultant; Self; Lilly Diabetes, Sanofi. Funding National Institute of Diabetes and Digestive and Kidney Diseases