Raman microprobe spectroscopic studies of solid DNA-CTMA films
2008
Extensive studies have been carried out on developing the new biopolymer, deoxyribonucleic acid (DNA) derived
from salmon, that has been complexed with a surfactant to make it water insoluble for application to bioelectronic
and biophotonic devices. One of the key issues associated with the properties and behavior of solid films of this
material is the extreme size of the >8 MDa molecular weight of the virgin, as-received material. Reduction of this
molecular weight by factors of up to 40 is achieved by high power sonication. To support the various measurements
that have been made to confirm that the sonicated material is still double strand DNA and to look for other effects of
sonication, Raman studies were carried out to compare the spectra over a wide range of molecular weights and to
develop baseline data that can be used in intercolation studies where various dopants are added to change the
electrical, mechanical or optical properties. Raman microprobe spectra from solid, dry thin films of DNA with
molecular weights ranging from 200 kDa to >8 MDa complexed with cetyltrimethyl-ammonium chloride (CTMA)
are reported and compared to the as-received spectrum and to published DNA spectra in aqueous solutions. In
addition, microscopy and measurements on macro-molecular structures of DNA-CTMA are reported.
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