Dynamic optical angiography of mouse anatomy using radial projections
2010
We demonstrate the feasibility of optical angiography on live mice using a new photoacoustic computed tomography
(PCT) scanner. The scanner uses a sparse array of discrete ultrasound detectors geometrically arranged to capture 128
simultaneous radial "projections" through a 25-mm-diameter volume of interest. Denser sets of interleaved radial
projections are acquired by rotating the sparse array continuously about its vertical axis during data acquisition. The
device has been designed specifically for imaging laboratory mice, which remain stationary during data collection.
Angiographic data are acquired at a rate of 1280 radial projections per second following a bolus injection of 2 mg/mL of
indocyanine green (ICG).
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