Morning for irofulven, what could be fiNER?
2021
Cancers with DNA repair dysfunction are vulnerable to DNA-damaging agents that invoke a requirement for the disabled repair mechanism. Genome sequencing, coupled with a detailed understanding of mechanisms of DNA repair, has accelerated the discovery of pathway-selective agents that target DNA repair deficiencies in a tumor tissue agnostic manner. See related articles by Borcsok et al., p. xxx and Topka et al., p. xxx
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