2 WEIGHT LOSS IS A FEATURE OF PROTRACTED METFORMIN THERAPY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME.

In 296 women with polycystic ovary syndrome (PCOS) treated with metformin (MET 2.3 ± 0.4 g/day [Rx]) and diet (1,500 calories/day if BMI Despite pretreatment (Pre-Rx) group severe obesity, MET-diet was successful in producing group weight reductions of 5.9% at 1 year, 5.8% at 2 years, and 6.3% at 3 years. Weight loss $ 5% was realized by 55% of women at 1 year, 55% at 2 years, and 58% at 3 years, with 15% or more weight loss in 11% of women at 1 year, 14% at 2 years, and 16% at 3 years. At years 1-3 on Rx, weight fell ( p