Caspase-1 and ASC but not NLRP3 mediate antifungal defense in candidiasis sepsis

IL-1β plays an important role in antifungal defense. The inflammasome is thought to be required for caspase-1 activation and processing of the inactive precursor pro-IL-1β into its active form. Contradictory data have been reported regarding the role of the inflammasome in Candida sepsis. In order to address these discrepancies, we investigated host defense against disseminated candidiasis in knockout mice defective in the various components of the inflammasome.