A Surrogate Matrix-Based Approach Toward Multiplexed Quantitation of an sGC Stimulator and cGMP in Ocular Tissue and Plasma.

Kenneth Lin,Pablo Cabral,Oscar Ekpenyong,Suzy El Bader,Joana Galvao,Yeonil Kim,Sherry X. Lu,Yu Tong Tam,Marc Bruder,Paul Rearden,Harish Shankaran,Maribel Beaumont

A Surrogate Matrix-Based Approach Toward Multiplexed Quantitation of an sGC Stimulator and cGMP in Ocular Tissue and Plasma.

2020

Kenneth Lin
Pablo Cabral
Oscar Ekpenyong
Suzy El Bader
Joana Galvao
Yeonil Kim
Sherry X. Lu
Yu Tong Tam
Marc Bruder
Paul Rearden
Harish Shankaran
Maribel Beaumont

A liquid chromatography–tandem mass spectrometry assay was developed and qualified for the multiplexed quantitation of a small molecule stimulator of soluble guanylate cyclase (sGC) and its target ...

Keywords:

Chromatography
Mass spectrometry
Chemistry
Small molecule
Cyclic guanosine monophosphate
Guanylate cyclase
ocular tissue

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